Clinical Development

CLINICAL STUDY

臨床試驗

Autologous Fibroblast Therapy for Moderate to Severe Nasolabial Fold Wrinkles in Adults – Phase II

Clinical Trial: In collaboration with Taipei Medical University

A characteristic of skin aging is the loss of extracellular matrix in connective tissue, such as collagen and elastin, leading to the formation of wrinkles. Injecting fibroblasts can increase collagen production, which enhances the thickness and density of skin collagen, thereby improving the severity of wrinkles without triggering inflammatory reactions. In this clinical trial, skin biopsies were taken from the participants’ post-auricular (behind the ear) region. The fibroblasts were isolated and cultured in the laboratory of MaWang Company. A concentration of 1.6-2.4×10^7 cells/ml was administered to the nasolabial folds of the participants every two weeks, for a total of three treatments. The improvement in the depth of the nasolabial fold depression was evaluated.

Autologous Skin Fibroblast Transplantation Technology for Treating Skin Wounds, Scars, and Other Skin Deficiency Diseases – Phase I

Clinical Trial: In collaboration with Taipei Medical University (Trial concluded)

Currently, there is no optimal treatment for depressed scars in clinical practice. Fibroblast therapy can smooth scars, wrinkles, and rapidly repair wounds in patients with skin deficiencies, making it a simple, safe, low-side-effect, and long-lasting new treatment. This technology has been practiced abroad for many years and is now being considered for routine treatments. It is expected to be expanded for use in burn scars, diabetic skin ulcers, and patients with congenital or acquired skin atrophy diseases who require autologous skin grafts. This technique offers continued maintenance and supplementation in clinical settings, helping to avoid the drawbacks of autologous skin graft surgeries and insufficient donor skin areas.

PRECLINICAL STUDY

臨床前試驗

Evaluation of the Efficacy of Skin-Derived Mesenchymal Stem Cells in Treating Mood Disorders

Collaborative Research with National Taiwan Normal University: Investigating the Therapeutic Effects of Skin-Derived Mesenchymal Stem Cells in a Mouse Model of Depression.

Neuroinflammation and increased cellular oxidative stress are some of the primary causes of mood disorders, including depression. This preclinical animal study focuses on treating depressive mice with skin-derived mesenchymal stem cells to suppress inflammation and restore the balance of oxidative stress. The goal is to evaluate whether these stem cells can alleviate symptoms in the animal model of depression.

Evaluation of the Efficacy of Skin-Derived Mesenchymal Stem Cells in Treating Diabetes and Osteoporosis

Collaborative Research with the National Defense Medical Center: Investigating the Therapeutic Effects of Skin-Derived Mesenchymal Stem Cells in a Mouse Model of Diabetes.

Type 1 diabetes is primarily caused by the autoimmune destruction of pancreatic β-cells, leading to an absolute insulin deficiency. This preclinical animal study aims to evaluate the efficacy of skin-derived mesenchymal stem cells in treating diabetic mice, specifically to assess whether these stem cells can improve symptoms in the animal model of Type 1 diabetes.

Evaluation of the Hair Growth Efficacy of Dermal Papilla Cells

Commissioned by the National Laboratory Animal Center, National Applied Research Laboratories: Studying the hair growth efficacy of dermal papilla cells using an immunodeficient mouse model.

This preclinical animal study mainly involves transplanting human dermal papilla cells under the skin of immunodeficient mice to observe whether these cells can continue to grow, differentiate, and induce hair growth under the mice’s skin, with the goal of promoting hair growth.

Evaluation of the Hair Growth Efficacy of Hair Regeneration Freeze-Dried Essence

Purified human dermal mesenchymal stem cells secrete hair-regenerating growth factors. These are preserved in sterile vacuum packaging to maintain their activity. The essence also contains extracts of Angelica sinensis and ginseng. Through a full absorption mechanism, the hair follicles receive the necessary nutrients, creating a healthy scalp environment and stimulating hair growth.

Schedule

研究排程

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