Popular science on cell therapy
Regenerative medicine
Regenerative medicine is a field of clinical medicine focused on repairing damaged cell functions or tissues. It encompasses novel medical devices, tissue engineering, and cell therapy. The U.S. National Institutes of Health (NIH) defines regenerative medicine and tissue engineering as the use of healthy cells to repair, reorganize, and replace the functions of damaged cells or tissues, allowing injured cells or tissues to regain functionality.
Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) can be derived from sources such as skin, fat, umbilical cord blood, amniotic membrane, and bone marrow. They have the ability to self-renew and differentiate into multiple cell types. They are relatively easy to isolate and culture, and they proliferate quickly in vitro. They can be induced to differentiate into liver, cartilage, muscle, and nervous system cells, greatly increasing the feasibility of their use in clinical cell therapy applications.
- Amniotic Membrane-Derived Stem Cells
Amniotic membrane-derived stem cells are sampled from the amniotic membrane. Through standardized processes, the amniotic membrane-derived stem cells cultured by MaWang Company conform to the basic characteristics of mesenchymal stem cells, expressing positive markers for CD73, CD90, and CD105, and negative for CD45. They have the capability to differentiate into adipose (adipogenesis), cartilage (chondrogenesis), and bone (osteogenesis), ensuring that the cells retain their differentiation potential even after being expanded in culture. - Skin-Derived Stem Cells
Skin-derived stem cells (SDSC) are sampled from the skin. Through standardized processes, the skin-derived stem cells cultured by MaWang Company conform to the basic characteristics of mesenchymal stem cells, expressing positive markers for CD73, CD90, and CD105, and negative for CD45. They also have the capability to differentiate into adipose (adipogenesis), cartilage (chondrogenesis), and bone (osteogenesis), ensuring that the cells retain their differentiation potential even after being expanded in culture.
Fibroblast
Fibroblasts are a type of important connective tissue cell whose main function is to synthesize and secrete the extracellular matrix (ECM). The ECM is the primary component of connective tissue and includes collagen, elastin, and fibronectin, among others.
Fibroblasts are also found in the connective tissues of the human body, such as skin, tendons, liver, and spleen. They are polymorphic cells with diverse and variable characteristics, capable of synthesizing ECMs that support different organs, fulfilling the needs of various tissues.
During human growth, injury recovery, and disease healing processes, fibroblasts play a crucial role. For example, during wound healing, fibroblasts migrate to the periphery of the wound and begin synthesizing and secreting ECM to form new tissue. Moreover, when certain tissues are damaged, fibroblasts can rapidly proliferate to replace lost cells and ECM, maintaining the structural and functional integrity of the tissues.
Introduction to Mariavon’s Special Management Measures (Indications and Applications)
Introduction to Mariavon’s Special Management Measures
(Indications and Applications)
Autologous Fibroblast Therapy
Aging, environmental dryness, and ultraviolet exposure are factors that lead to skin aging. To promote skin repair, supplementing collagen is essential.
Fibroblasts are one of the cells in the skin responsible for secreting collagen, helping to repair the skin by increasing elasticity and reducing the formation of wrinkles.
In addition, fibroblasts secrete fibroblast growth factors, stimulating cell proliferation, as well as vascular endothelial growth factors, which promote nutrient transport. These functions help maintain cell activity and contribute to skin repair.
Cell Therapy Project：Autologous Fibroblast Therapy
Indications：Skin defects: wrinkles, depressions, and scars requiring filling and repair
Detailed Indications：Autologous fibroblast transplantation therapy for “skin defects: wrinkles, depressions, and scars requiring filling and repair”
Partnering Hospital：Cathay General Hospital, Cathay Medical Foundation
Treatment Process
How to Obtain Autologous Fibroblasts?
Fibroblasts are isolated from the dermis of skin collected by the hospital and are then applied to repair and regenerate skin defects and soft tissue. This promotes wound healing and the production of new collagen.
1. Hospital Consultation
A physician will provide a consultation to assess treatment needs and conditions.
2. Blood Testing
Blood tests are conducted to screen for statutory infectious diseases, such as HIV, syphilis, hepatitis B, and hepatitis C.
3. Skin Tissue Collection
After screening for infectious diseases and signing an informed consent form, tissue is collected from behind the ear.
4. Cell Preparation
The collected tissue is processed for purification and fibroblast preparation.
5. Follow-up Injection
A complete autologous fibroblast treatment requires three injections, scheduled two weeks apart. Follow-up monitoring is conducted for one year.
GTP certification
COMPANY INFORMATION
Address: 7th Floor, No. 29-1, Lane 169, Kangning Street, Xizhi District, New Taipei City
Phone：+886-2-2693-3232
Email：information_mv@mariavon.com.tw
